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顶部生物活性储存和溶解信息计算器

Anti-Phospho-STAT3 (Tyr705) Antibody (3X472)

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产品编号 TMAB-11323

Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) 是一种 Rabbit 抗体，靶向 Phospho-STAT3 (Tyr705)。Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-Phospho-STAT3 (Tyr705) Antibody (3X472)

Anti-Phospho-STAT3 (Tyr705) Antibody (3X472)

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-11323

Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) 是一种 Rabbit 抗体，靶向 Phospho-STAT3 (Tyr705)。Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
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100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) is a Rabbit antibody targeting Phospho-STAT3 (Tyr705). Anti-Phospho-STAT3 (Tyr705) Antibody (3X472) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
3X472
交叉反应
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1.
组织特异性Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
抗原信息
免疫原
A synthesized peptide: human STAT3 around the phosphorylation site of Y705
抗原种属
Human
基因名称
STAT3
基因ID
6774
蛋白名称
Signal transducer and activator of transcription 3
Uniprot ID
P40763
功能
Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA.
化学信息
分子量Theoretical: 85 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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