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顶部生物活性储存和溶解信息计算器

Anti-Phospho-Shc (Tyr427) Polyclonal Antibody

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Anti-Phospho-Shc (Tyr427) Polyclonal Antibody
产品编号 TMAC-03738
别名 Shc (p-Y427), Shc (p-Tyr427), p-Shc (Y427), p-Shc (Tyr427)

Anti-Phospho-Shc (Tyr427) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Shc (Tyr427)。Anti-Phospho-Shc (Tyr427) Polyclonal Antibody 可用于 WB,IHC,IF。

Anti-Phospho-Shc (Tyr427) Polyclonal Antibody

Anti-Phospho-Shc (Tyr427) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody
产品编号 TMAC-03738 别名 Shc (p-Y427), Shc (p-Tyr427), p-Shc (Y427), p-Shc (Tyr427)

Anti-Phospho-Shc (Tyr427) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-Shc (Tyr427)。Anti-Phospho-Shc (Tyr427) Polyclonal Antibody 可用于 WB,IHC,IF。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-Shc (Tyr427) Polyclonal Antibody is a Rabbit antibody targeting Phospho-Shc (Tyr427). Anti-Phospho-Shc (Tyr427) Polyclonal Antibody can be used in WB,IHC,IF.
别名Shc (p-Y427), Shc (p-Tyr427), p-Shc (Y427), p-Shc (Tyr427)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from 293 cells untreated or treated with PMA using Shc1 (Phospho-Tyr427) Antibody TMAC-03738.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Shc1 (Phospho-Tyr427) Antibody TMAC-03738 (left) or the same antibody preincubated with blocking peptide (right).
3. Immunofluorescence staining of methanol-fixed Hela cells using Shc1 (Phospho-Tyr427) Antibody TMAC-03738.
应用
WB
IHC
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 427 (P-S-Y(p)-V-N derived from Human Shc1
抗原种属
human
Uniprot ID
P29353
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

Shc (pY427)Shc (pTyr427)Shc (phospho-Y427)Shc (phospho-Tyr427)pShc (Y427)pShc (Tyr427)

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