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Anti-Phospho-MAPT (Ser416) Polyclonal Antibody
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产品编号 TMAC-03981
别名 p-MAPT (Ser416), p-MAPT (S416), MAPT (p-Ser416), MAPT (p-S416)
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MAPT (Ser416)。Anti-Phospho-MAPT (Ser416) Polyclonal Antibody 可用于 WB。
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody
还可以产品编号 TMAC-03981 别名 p-MAPT (Ser416), p-MAPT (S416), MAPT (p-Ser416), MAPT (p-S416)
Anti-Phospho-MAPT (Ser416) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MAPT (Ser416)。Anti-Phospho-MAPT (Ser416) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-MAPT (Ser416) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MAPT (Ser416). Anti-Phospho-MAPT (Ser416) Polyclonal Antibody can be used in WB. |
| 别名 | p-MAPT (Ser416), p-MAPT (S416), MAPT (p-Ser416), MAPT (p-S416) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Tau (phospho-Ser416) Antibody TMAC-03981. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of serine 416 (T-G-S(p)-I-D) derived from Human Tau |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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