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Anti-Phospho-MAPT (S396) Antibody (4F595) 是一种 Rabbit 抗体,靶向 Phospho-MAPT (S396)。Anti-Phospho-MAPT (S396) Antibody (4F595) 可用于 WB,ICC/IF,IHC。
Anti-Phospho-MAPT (S396) Antibody (4F595) 是一种 Rabbit 抗体,靶向 Phospho-MAPT (S396)。Anti-Phospho-MAPT (S396) Antibody (4F595) 可用于 WB,ICC/IF,IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,490 | 5日内发货 | |
100 μL | ¥ 2,485 | 5日内发货 |
产品描述 | Anti-Phospho-MAPT (Ser396) Antibody (4F595) 是一种 Rabbit 抗体,靶向 Phospho-MAPT (Ser396)。Anti-Phospho-MAPT (Ser396) Antibody (4F595) 可用于 WB,ICC/IF,IHC。 |
别名 | p-MAPT (Ser396), p-MAPT (S396), MAPT (p-Ser396), MAPT (p-S396) |
Ig Type | IgG |
交叉反应 | Human,Mouse,Rat |
验证活性 | 1. All lanes use the Antibody at 1:4K dilution for 1 hour at room temperature. 2. Western blot analysis of Phospho-Tau (S396) expression in (1) SH-SY5Y cell lysate treated with AP; (2) SH-SY5Y cell lysate. 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-Tau (S396) Antibody. 4. All lanes use the Antibody at 1:400 dilution for 1 hour at room temperature. |
应用 | |
推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:100-500 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | Recombinant Antibody |
纯化方式 | ProA affinity purified |
性状 | Liquid |
缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
研究背景 | Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, in addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). |
偶联 | Unconjugated |
其他可选修饰符 | Phospho |
免疫原 | A synthesized phosphopeptide: human Tau around the phosphorylation site of Ser396 |
抗原种属 | human |
Uniprot ID |
分子量 | Theoretical: 80 kDa. |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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