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顶部生物活性储存和溶解信息计算器

Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody

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Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody
产品编号 TMAC-02128
别名 p-IKBKB (Y188), p-IKBKB (Tyr188), IKBKB (p-Y188), IKBKB (p-Tyr188)

Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKBKB (Tyr188)。Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody

Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody
产品编号 TMAC-02128 别名 p-IKBKB (Y188), p-IKBKB (Tyr188), IKBKB (p-Y188), IKBKB (p-Tyr188)

Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-IKBKB (Tyr188)。Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody is a Rabbit antibody targeting Phospho-IKBKB (Tyr188). Anti-Phospho-IKBKB (Tyr188) Polyclonal Antibody can be used in WB,IHC.
别名p-IKBKB (Y188), p-IKBKB (Tyr188), IKBKB (p-Y188), IKBKB (p-Tyr188)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from COS7 tissue using IKK-beta (Phospho-Tyr188) antibody TMAC-02128. The lane on the right is treated with the antigen-specific peptide.
2. Immunohistochemical analysis of paraffin-embedded Human breast cancer. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.
3. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using IKK-beta (Phospho-Tyr188) Antibody. The picture on the right is blocked with the phospho peptide.
应用
WB
IHC
推荐剂量
WB: 1:500-2000; IHC: 1:100-300
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of tyrosine 188 (L-Q-Y(p)-L-A) derived from Human IKK- beta
抗原种属
human
Uniprot ID
O14920
化学信息
分子量Actual: 87 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pIKBKB (Y188)pIKBKB (Tyr188)IKBKB (pY188)IKBKB (pTyr188)IKBKB (phospho-Y188)IKBKB (phospho-Tyr188)

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