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Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody

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产品编号 TMAB-10770

Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155)。Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody

Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAB-10770

Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155)。Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,165
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
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产品介绍

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产品描述
Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155). Anti-Phospho-HDAC4/HDAC5/HDAC7 (Ser246/Ser259/Ser155) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,IF.
Ig Type
IgG
交叉反应
Human,Mouse (predicted:Rat,Chicken,Cow,Horse,Rabbit)
应用WBIHC-PIHC-FrIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
组织特异性Ubiquitous.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human HDAC4 around the phosphorylation site of Ser246
抗原种属
Human
基因名称
HDAC4
基因ID
9759
蛋白名称
Histone deacetylase 4
Uniprot ID
P56524
功能
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
化学信息
分子量Theoretical: 119 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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