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Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

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Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody
产品编号 TMAC-01769
别名 p-HDAC1 (Ser421), p-HDAC1 (S421), HDAC1 (p-Ser421), HDAC1 (p-S421)

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-HDAC1 (Ser421)。Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody 可用于 WB。

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody
产品编号 TMAC-01769 别名 p-HDAC1 (Ser421), p-HDAC1 (S421), HDAC1 (p-Ser421), HDAC1 (p-S421)

Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-HDAC1 (Ser421)。Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody is a Rabbit antibody targeting Phospho-HDAC1 (Ser421). Anti-Phospho-HDAC1 (Ser421) Polyclonal Antibody can be used in WB.
别名p-HDAC1 (Ser421), p-HDAC1 (S421), HDAC1 (p-Ser421), HDAC1 (p-S421)
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of extracts from HepG2 cells using HDAC1 (Phospho-Ser421) Antibody TMAC-01769. The lane on the left is treated with the antigen-specific peptide.
应用
WB
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Component a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of Serine 421 (E-F-S(p)-D-S) derived from Human HDAC1
抗原种属
human
Uniprot ID
Q13547
化学信息
分子量Actual: 62 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pHDAC1 (Ser421)pHDAC1 (S421)HDAC1 (pSer421)HDAC1 (pS421)HDAC1 (phospho-Ser421)HDAC1 (phospho-S421)

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4个月前
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