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Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 2
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产品编号 TMAC-01462
别名 p-FGFR1 (Y654), p-FGFR1 (Tyr654), FGFR1 (p-Y654), FGFR1 (p-Tyr654)
Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FGFR1 (Tyr654)。Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 可用于 WB。
Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 2
Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 2
还可以产品编号 TMAC-01462 别名 p-FGFR1 (Y654), p-FGFR1 (Tyr654), FGFR1 (p-Y654), FGFR1 (p-Tyr654)
Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-FGFR1 (Tyr654)。Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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| 产品描述 | Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody is a Rabbit antibody targeting Phospho-FGFR1 (Tyr654). Anti-Phospho-FGFR1 (Tyr654) Polyclonal Antibody can be used in WB. |
| 别名 | p-FGFR1 (Y654), p-FGFR1 (Tyr654), FGFR1 (p-Y654), FGFR1 (p-Tyr654) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from 293 cells treated with insulin using FGFR1 (Phospho-Tyr654) Antibody TMAC-01462. The lane on the right is treated with the antigen-specific peptide. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of Tyrosine 654 (D-Y-Y(p)-K-K) derived from Human FGFR1 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 120 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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