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顶部生物活性储存和溶解信息计算器

Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody

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Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody
产品编号 TMAC-01279
别名 p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231)

Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-EIF4G1 (Ser1231)。Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody

Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody
产品编号 TMAC-01279 别名 p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231)

Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-EIF4G1 (Ser1231)。Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,235
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody is a Rabbit antibody targeting Phospho-EIF4G1 (Ser1231). Anti-Phospho-EIF4G1 (Ser1231) Polyclonal Antibody can be used in WB,IHC.
别名p-EIF4G1 (Ser1231), p-EIF4G1 (S1231), EIF4G1 (p-Ser1231), EIF4G1 (p-S1231)
Ig Type
IgG
交叉反应
Human
验证活性
1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using eIF4G (phospho-Ser1231) Antibody TMAC-01279 (left) or the same antibody preincubated with blocking peptide (right).
2. Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using eIF4G (phospho-Ser1231) Antibody TMAC-01279.
应用
WB
IHC
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 1231 (P-V-S(p)-P-L) derived from Human eIF4G
抗原种属
human
Uniprot ID
Q04637
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pEIF4G1 (Ser1231)pEIF4G1 (S1231)EIF4G1 (pSer1231)EIF4G1 (pS1231)EIF4G1 (phospho-Ser1231)EIF4G1 (phospho-S1231)

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