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顶部生物活性储存和溶解信息计算器

Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580)

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产品编号 TMAB-10630

Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) 是一种 Rabbit 抗体，靶向 Phospho-EIF2S1 (Ser51)。Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580)

Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580)

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10630

Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) 是一种 Rabbit 抗体，靶向 Phospho-EIF2S1 (Ser51)。Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) is a Rabbit antibody targeting Phospho-EIF2S1 (Ser51). Anti-Phospho-EIF2S1 (Ser51) Antibody (2V580) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,FCM.
Ig Type
IgG
克隆号
2V580
交叉反应
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景eIF2 alpha is a 36 kDa protein which is ubiquitously expressed in many cell types. The eIF2 protein, which is composed of three subunits (alpha, beta and gamma), is one of the key molecules in the initiation of translation. In mammalian cells, eIF2 alpha is phosphorylated at serine 51 (human EIF2 alpha, the equivalent residue in mouse is serine 52) by at least two kinases: the haem-controlled repressor (HCR) and the interferon inducible double stranded RNA-dependent protein kinase (PKR). Phosphorylation of eIF2 alpha blocks the GDP-GTP exchange activity of eIF2 beta, resulting in the suppression of protein synthesis. The phosphorylation of eIF2 alpha is an important regulatory process in protein synthesis.
抗原信息
免疫原
A synthesized peptide: human eIF2A around the phosphorylation site of S51
抗原种属
Human
基因名称
EIF2S1
基因ID
1965
蛋白名称
Eukaryotic translation initiation factor 2 subunit 1
Uniprot ID
P05198
功能
Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
化学信息
分子量Theoretical: 36 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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