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Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody
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产品编号 TMAC-00845
别名 p-CHEK2 (Thr387), p-CHEK2 (T387), CHEK2 (p-Thr387), CHEK2 (p-T387)
Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CHEK2 (Thr387)。Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody 可用于 WB。
Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody
Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody
还可以产品编号 TMAC-00845 别名 p-CHEK2 (Thr387), p-CHEK2 (T387), CHEK2 (p-Thr387), CHEK2 (p-T387)
Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CHEK2 (Thr387)。Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,230 | 5日内发货 |
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| 产品描述 | Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK2 (Thr387). Anti-Phospho-CHEK2 (Thr387) Polyclonal Antibody can be used in WB. |
| 别名 | p-CHEK2 (Thr387), p-CHEK2 (T387), CHEK2 (p-Thr387), CHEK2 (p-T387) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from Jurkat tissue using Chk2 (Phospho-Thr387) antibody TMAC-00845. The lane on the right is treated with the antigen-specific peptide. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of threonine 387 (C-G-T(p)-P-T) derived from Human Chk2 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 62 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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