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顶部生物活性储存和溶解信息计算器

Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody

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产品编号 TMAB-10479

Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CDKN1A/p21 (Thr145)。Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody

Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10479

Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CDKN1A/p21 (Thr145)。Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CDKN1A/p21 (Thr145). Anti-Phospho-CDKN1A/p21 (Thr145) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
交叉反应
Human,Mouse,Rat
应用IHC-PIHC-FrIFFCM
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 3μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasmic and Nuclear.
组织特异性Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
抗原信息
免疫原
KLH conjugated Synthesised phosphopeptide: human CDKN1A around the phosphorylation site of Thr145
抗原种属
Human
基因名称
CDKN1A
基因ID
1026
蛋白名称
Cyclin-dependent kinase inhibitor 1
Uniprot ID
P38936
功能
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
化学信息
分子量Theoretical: 18 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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