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Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody

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Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody
产品编号 TMAC-01041
别名 p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280)

Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CCND2 (Thr280)。Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody 可用于 WB。

Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody

Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody
产品编号 TMAC-01041 别名 p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280)

Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CCND2 (Thr280)。Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CCND2 (Thr280). Anti-Phospho-CCND2 (Thr280) Polyclonal Antibody can be used in WB.
别名p-CCND2 (Thr280), p-CCND2 (T280), CCND2 (p-Thr280), CCND2 (p-T280)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from COLO cells, treated with EGF (200ng/ml, 30mins), using Cyclin D2 (Phospho-Thr280) antibody TMAC-01041. The lane on the right is treated with the synthesized peptide.
应用
WB
推荐剂量
WB: 1:500-3000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of threonine 280 (A-S-T(p)-P-T) derived from Human Cyclin D2
抗原种属
human
Uniprot ID
P30279
化学信息
分子量Actual: 40 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

pCCND2 (Thr280)pCCND2 (T280)CCND2 (pThr280)CCND2 (pT280)CCND2 (phospho-Thr280)CCND2 (phospho-T280)

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