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Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody

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Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody
产品编号 TMAC-00564
别名 p-CARM1 (Ser228), p-CARM1 (S228), CARM1 (p-Ser228), CARM1 (p-S228)

Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CARM1 (Ser228)。Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody 可用于 WB,IF。

Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody

Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody

Rating icon 还可以
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody
产品编号 TMAC-00564 别名 p-CARM1 (Ser228), p-CARM1 (S228), CARM1 (p-Ser228), CARM1 (p-S228)

Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-CARM1 (Ser228)。Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody 可用于 WB,IF。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,230
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CARM1 (Ser228). Anti-Phospho-CARM1 (Ser228) Polyclonal Antibody can be used in WB,IF.
别名p-CARM1 (Ser228), p-CARM1 (S228), CARM1 (p-Ser228), CARM1 (p-S228)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of extracts from A431 cells untreated or treated with EGF (200ng/ml, 5min), using CARM1 (Ab-228) antibody (Line 1 and 2) and CARM1 (Phospho-Ser228) antibody (Line 3 and 4).
2. Immunofluorescence staining of methanol-fixed HeLa cells using CARM1 (Phospho-Ser228) antibody (TMAC-00564, Red).
应用
WB
IF
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of serine 228(V-K-S(p)-N-N) derived from Human CARM1
抗原种属
human
Uniprot ID
A6NN38
化学信息
分子量Actual: 63 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pCARM1 (Ser228)pCARM1 (S228)CARM1 (pSer228)CARM1 (pS228)CARM1 (phospho-Ser228)CARM1 (phospho-S228)

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