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Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody
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产品编号 TMAC-00511
别名 p-C-ABL/ABL1 (Y245), p-C-ABL/ABL1 (Tyr245), C-ABL/ABL1 (p-Y245), C-ABL/ABL1 (p-Tyr245)
Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-C-ABL/ABL1 (Tyr245)。Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody 可用于 WB。
Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody
Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody
还可以产品编号 TMAC-00511 别名 p-C-ABL/ABL1 (Y245), p-C-ABL/ABL1 (Tyr245), C-ABL/ABL1 (p-Y245), C-ABL/ABL1 (p-Tyr245)
Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-C-ABL/ABL1 (Tyr245)。Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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| 产品描述 | Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody is a Rabbit antibody targeting Phospho-C-ABL/ABL1 (Tyr245). Anti-Phospho-C-ABL/ABL1 (Tyr245) Polyclonal Antibody can be used in WB. |
| 别名 | p-C-ABL/ABL1 (Y245), p-C-ABL/ABL1 (Tyr245), C-ABL/ABL1 (p-Y245), C-ABL/ABL1 (p-Tyr245) |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of extracts from c-Abl Insulin treated K562 tissue using antibody TMAC-00511. The lane on the right is treated with the antigen-specific peptide. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of tyrosine 245 (T-V-Y(p)-G-V) derived from Human c-Abl |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 135 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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