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Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2
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还可以产品编号 TMAB-10374
Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Bax (Ser184)。Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ELISA。
Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2
Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-10374
Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-Bax (Ser184)。Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 可用于 WB,IHC-P,IHC-Fr,IF,FCM,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-Bax (Ser184). Anti-Phospho-Bax (Ser184) Polyclonal Antibody 2 can be used in WB,IHC-P,IHC-Fr,IF,FCM,ELISA. |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,Rabbit (predicted:Dog,Pig,Cow,Sheep) |
| 应用 | WBIHC-PIHC-FrIFFCMELISA |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 3μg/Test; ELISA: 1:5000-10000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Isoform Alpha: Mitochondrion membrane; Single-pass membrane protein. Cytoplasm. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane. Isoform Beta: Cytoplasm. Isoform Gamma: Cytoplasm. Isoform Delta: Cytoplasm (Potential). |
| 组织特异性 | Expressed in a wide variety of tissues. Isoform Psi is found in glial tumors. Isoform Alpha is expressed in spleen, breast, ovary, testis, colon and brain, and at low levels in skin and lung. Isoform Sigma is expressed in spleen, breast, ovary, testis, lung, colon, brain and at low levels in skin. Isoform Alpha and isoform Sigma are expressed in pro-myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma, ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma, lung carcinoma, epidermoid carcinoma, small cell lung carcinoma and colon adenocarcinoma cell lines. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008]. |
| 免疫原 | KLH conjugated Synthesised phosphopeptide: human Bax around the phosphorylation site of Ser184 |
| 抗原种属 | Human |
| 基因名称 | BAX |
| 基因ID | |
| 蛋白名称 | Apoptosis regulator BAX |
| Uniprot ID | |
| 功能 | Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. |
| 分子量 | Theoretical: 21 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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