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Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2
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还可以产品编号 TMAB-10373
Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-BAP1 (Ser592)。Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2
Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2
一键复制产品信息 还可以产品编号 TMAB-10373
Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-BAP1 (Ser592)。Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,795 | 5日内发货 |
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| 产品描述 | Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-BAP1 (Ser592). Anti-Phospho-BAP1 (Ser592) Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| 交叉反应 | Rat (predicted:Human,Dog,Rabbit) |
| 应用 | IHC-PIHC-FrIF |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Mainly nuclear. Binds to chromatin. |
| 组织特异性 | Highly expressed in testis, placenta and ovary. Expressed in breast. |
| 构建方式 | Hybridoma Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1mg/ml |
| 研究背景 | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified. Transcript Variant: This variant (BRCA1a') uses different splice site in the 5' UTR when compared to variant BRCA1a. It encodes the full-length BRCA1 protein (isoform 1) which is also known as p220. Variants BRCA1a and BRCA1b also encode the full-length BRCA1 protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| 免疫原 | KLH conjugated Synthesised phosphopeptide: human BAP1 around the phosphorylation site of Ser592 |
| 抗原种属 | Human |
| 基因名称 | BAP1 |
| 基因ID | |
| 蛋白名称 | Ubiquitin carboxyl-terminal hydrolase BAP1 |
| Uniprot ID | |
| 功能 | Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Acts as a tumor suppressor. |
| 分子量 | Theoretical: 81 kDa. |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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