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顶部生物活性储存和溶解信息计算器

Anti-Phospho-ATR (Ser428) Polyclonal Antibody

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产品编号 TMAC-00343

别名 p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428)

Anti-Phospho-ATR (Ser428) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATR (Ser428)。Anti-Phospho-ATR (Ser428) Polyclonal Antibody 可用于 IF,IHC。

Anti-Phospho-ATR (Ser428) Polyclonal Antibody

Anti-Phospho-ATR (Ser428) Polyclonal Antibody

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Rating icon 还可以
产品编号 TMAC-00343 别名 p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428)

Anti-Phospho-ATR (Ser428) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATR (Ser428)。Anti-Phospho-ATR (Ser428) Polyclonal Antibody 可用于 IF,IHC。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ATR (Ser428) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATR (Ser428). Anti-Phospho-ATR (Ser428) Polyclonal Antibody can be used in IF,IHC.
别名p-ATR (Ser428), p-ATR (S428), ATR (p-Ser428), ATR (p-S428)
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ATR (Phospho-Ser428) antibody TMAC-00343. The picture on the right is treated with the synthesized peptide.
verifiedActivity
应用IFIHC
推荐剂量
IHC: 1:100-300; IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human ATR around the phosphorylation site of Ser428
抗原种属
human
Uniprot ID
Q13535
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pATR (Ser428)pATR (S428)ATR (pSer428)ATR (pS428)ATR (phospho-Ser428)ATR (phospho-S428)

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4个月前
5.0
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