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Anti-Phospho-ATM (Ser1981) Polyclonal Antibody
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产品编号 TMAC-00336
别名 p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981)
Anti-Phospho-ATM (Ser1981) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATM (Ser1981)。Anti-Phospho-ATM (Ser1981) Polyclonal Antibody 可用于 WB,IHC。
Anti-Phospho-ATM (Ser1981) Polyclonal Antibody
Anti-Phospho-ATM (Ser1981) Polyclonal Antibody
还可以产品编号 TMAC-00336 别名 p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981)
Anti-Phospho-ATM (Ser1981) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ATM (Ser1981)。Anti-Phospho-ATM (Ser1981) Polyclonal Antibody 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,240 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-ATM (Ser1981) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ATM (Ser1981). Anti-Phospho-ATM (Ser1981) Polyclonal Antibody can be used in WB,IHC. |
| 别名 | p-ATM (Ser1981), p-ATM (S1981), ATM (p-Ser1981), ATM (p-S1981) |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of extracts from Hela cells untreated or treated with UV using ATM(Phospho-Ser1981) Antibody TMAC-00336. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ATM(Phospho-Ser1981) Antibody TMAC-00336(left) or the same antibody preincubated with blocking peptide(right). |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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