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Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2

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产品编号 TMAB-10344

Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-ATF2 (Ser480)。Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 可用于 WB。

Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2

Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2

一键复制产品信息
Rating icon 还可以
产品编号 TMAB-10344

Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Phospho-ATF2 (Ser480)。Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 is a Rabbit antibody targeting Phospho-ATF2 (Ser480). Anti-Phospho-ATF2 (Ser480) Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
交叉反应
Human (predicted:Mouse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Abundant expression seen in the brain.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.
抗原信息
免疫原
KLH conjugated synthesised phosphopeptide: human ATF2 around the phosphorylation site of Ser480
抗原种属
Human
基因名称
ATF2
基因ID
1386
蛋白名称
Cyclic AMP-dependent transcription factor ATF-2
Uniprot ID
P15336
功能
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.
化学信息
分子量Theoretical: 45 kDa.
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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