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Anti-Phospho-APP (Thr668) Polyclonal Antibody
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产品编号 TMAC-00249
别名 p-APP (Thr668), p-APP (T668), APP (p-Thr668), APP (p-T668)
Anti-Phospho-APP (Thr668) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-APP (Thr668)。Anti-Phospho-APP (Thr668) Polyclonal Antibody 可用于 WB。
Anti-Phospho-APP (Thr668) Polyclonal Antibody
Anti-Phospho-APP (Thr668) Polyclonal Antibody
还可以产品编号 TMAC-00249 别名 p-APP (Thr668), p-APP (T668), APP (p-Thr668), APP (p-T668)
Anti-Phospho-APP (Thr668) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-APP (Thr668)。Anti-Phospho-APP (Thr668) Polyclonal Antibody 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,235 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Phospho-APP (Thr668) Polyclonal Antibody is a Rabbit antibody targeting Phospho-APP (Thr668). Anti-Phospho-APP (Thr668) Polyclonal Antibody can be used in WB. |
| 别名 | p-APP (Thr668), p-APP (T668), APP (p-Thr668), APP (p-T668) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of extracts from mouse brain tissue using APP(Phospho-668) Antibody TMAC-00249(Lane 2) and the same antibody preincubated with blocking peptide(Lane1). 2. Western blot analysis of extracts from Hela cells, treated with Noc or calf intestinal phosphatase (CIP), using APP (Phospho-Thr668) Antibody TMAC-00249. |
| 应用 | |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 性状 | Liquid |
| 缓冲液 | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | Peptide sequence around phosphorylation site of threonine 668 (A-V-T(p)-P-E) derived from Human APP |
| 抗原种属 | human |
| Uniprot ID |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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