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顶部生物活性储存和溶解信息计算器

Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody

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产品编号 TMAC-00052
别名 p-ACAP1 (Ser554), p-ACAP1 (S554), ACAP1 (p-Ser554), ACAP1 (p-S554)

Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ACAP1 (Ser554)。Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody 可用于 ELISA,IF,IHC-P,WB。

Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody

Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
产品编号 TMAC-00052 别名 p-ACAP1 (Ser554), p-ACAP1 (S554), ACAP1 (p-Ser554), ACAP1 (p-S554)

Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-ACAP1 (Ser554)。Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody 可用于 ELISA,IF,IHC-P,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,245
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody is a Rabbit antibody targeting Phospho-ACAP1 (Ser554). Anti-Phospho-ACAP1 (Ser554) Polyclonal Antibody can be used in ELISA,IF,IHC-P,WB.
别名p-ACAP1 (Ser554), p-ACAP1 (S554), ACAP1 (p-Ser554), ACAP1 (p-S554)
Ig Type
IgG
交叉反应
Human
应用ELISAIFIHC-PWB
推荐剂量
IHC-P: 1:100-300; ELISA: 1:40000
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
性状Liquid
缓冲液Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
研究背景domain:PH domain binds phospholipids including phosphatidic acid, phosphatidylinositol 3-phosphate, phosphatidylinositol 3,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3). May mediate ACAP1-binding to PIP2 or PIP3 containing membranes.,enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.,function:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.,miscellaneous:Cells overexpressing ACAP1 show an accumulation of ITGB1 in recycling endosomes and inhibition of stimulation-dependent cell migration. Cells with reduced levels of ACAP1 or AKT1 and AKT2 show inhibition of stimulation-dependent cell migration. Cells overexpressing ACAP1 and PIP5K1C show formation of tubular structures derived from endosomal membranes.,PTM:Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 1 BAR domain.,similarity:Contains 1 PH domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with GTP-bound ARF6. Interacts with third cytoplasmic loop of SLC2A4/GLUT4. Interacts with CLTC. Interacts with GULP1. Forms a complex with GDP-bound ARF6 and GULP1.,tissue specificity:Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas.,
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human Centaurin-beta1 around the phosphorylation site of Ser554. AA range:520-569
抗原种属
human
Uniprot ID
Q15027
化学信息
分子量Theoretical: 81 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pACAP1 (Ser554)pACAP1 (S554)ACAP1 (pSer554)ACAP1 (pS554)ACAP1 (phospho-Ser554)ACAP1 (phospho-S554)

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