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Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
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产品编号 TMAC-00028
别名 p-53BP1 (Ser6), p-53BP1 (S6), 53BP1 (p-Ser6), 53BP1 (p-S6)
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-53BP1 (Ser6)。Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody
还可以产品编号 TMAC-00028 别名 p-53BP1 (Ser6), p-53BP1 (S6), 53BP1 (p-Ser6), 53BP1 (p-S6)
Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-53BP1 (Ser6)。Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody 可用于 WB,IHC-P,IF(paraffin section),ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,495 | 5日内发货 | |
| 100 μL | ¥ 2,235 | 5日内发货 |
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| 产品描述 | Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody is a Rabbit antibody targeting Phospho-53BP1 (Ser6). Anti-Phospho-53BP1 (Ser6) Polyclonal Antibody can be used in WB,IHC-P,IF(paraffin section),ELISA. |
| 别名 | p-53BP1 (Ser6), p-53BP1 (S6), 53BP1 (p-Ser6), 53BP1 (p-S6) |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,Monkey |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-300; ELISA: 1:5000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 性状 | Liquid |
| 缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 研究背景 | function:May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Plays a role in the response to DNA damage.,PTM:Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding.,PTM:Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation.,similarity:Contains 2 BRCT domains.,subcellular location:Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks. Methylation of histone H4 at 'Lys-20' is required for efficient localization to double strand breaks.,subunit:Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H4 that has been dimethylated at 'Lys-20'. Has low affinity for histone H4 containing monomethylated 'Lys-20'. Does not bind histone H4 containing unmethylated or trimethylated 'Lys-20'. Has low affinity for histone H3 that has been dimethylated on 'Lys-79'. Has very low affinity for histone H3 that has been monomethylated on 'Lys-79' (in vitro). Does not bind unmethylated histone H3., |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Phospho |
| 免疫原 | A synthesized phosphopeptide: human 53BP1 around the phosphorylation site of Ser6. AA range:1-50 |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Actual: 213 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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