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Anti-PBK/TOPK Antibody (4O108)
还可以产品编号 TMAY-01108
Anti-PBK/TOPK Antibody (4O108) 是一种 Mouse 抗体，靶向 PBK/TOPK。Anti-PBK/TOPK Antibody (4O108) 可用于 WB,ELISA,ELISA(Det)。
Anti-PBK/TOPK Antibody (4O108)
Anti-PBK/TOPK Antibody (4O108)
还可以产品编号 TMAY-01108
Anti-PBK/TOPK Antibody (4O108) 是一种 Mouse 抗体，靶向 PBK/TOPK。Anti-PBK/TOPK Antibody (4O108) 可用于 WB,ELISA,ELISA(Det)。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-PBK/TOPK Antibody (4O108) is a Mouse antibody targeting PBK/TOPK. Anti-PBK/TOPK Antibody (4O108) can be used in WB,ELISA,ELISA(Det). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4O108 |
| 交叉反应 | Human |
| 验证活性 | Anti-PBK mouse monoclonal antibody at 1:500 dilution. -Lane A: SW480 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:36 kDa. -Observed band size:38 kDa |
| 应用 | WB,ELISA,ELISA(Det) |
| 推荐剂量 | WB: 1:500-1:1000; ELISA: 1:5000-1:10000; ELISA(Det): 1:5000-1:50000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PBK / TOPK (rh PBK; TMPY-04547; NP_060962.2; Met 1-Val 322). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. This mitotic kinase phosphorylates MAP kinase p38 and seems to be active in mitosis. When phosphorylated, PBK forms a protein-protein interaction with tumor suppressor p53 (TP53), leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. The expression level of PBK is thus upregulated in a variety of neoplasms including hematological malignancies. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human PBK protein (TMPY-04547) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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