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Anti-p53R2 Antibody (4V66)
还可以产品编号 TMAY-02507
别名 ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A
Anti-p53R2 Antibody (4V66) 是一种 Mouse 抗体，靶向 p53R2。Anti-p53R2 Antibody (4V66) 可用于 WB,ELISA,ELISA(Det)。
Anti-p53R2 Antibody (4V66)
Anti-p53R2 Antibody (4V66)
还可以产品编号 TMAY-02507 别名 ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A
Anti-p53R2 Antibody (4V66) 是一种 Mouse 抗体，靶向 p53R2。Anti-p53R2 Antibody (4V66) 可用于 WB,ELISA,ELISA(Det)。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 580 | 5日内发货 | |
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-p53R2 Antibody (4V66) is a Mouse antibody targeting p53R2. Anti-p53R2 Antibody (4V66) can be used in WB,ELISA,ELISA(Det). |
| 别名 | ribonucleotide reductase M2 B (TP53 inducible), P53R2, MTDPS8B, MTDPS8A |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4V66 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-RRM2B mouse monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:40 kDa. -Observed band size:40 kDa. 2. Anti-RRM2B mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: RRM2B knockout 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:40 kDa. -Observed band size:39 kDa |
| 应用 | WB,ELISA,ELISA(Det) |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:5000-1:10000; ELISA(Det): 1:5000-1:50000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human RRM2B / P53R2 (rh RRM2B / P53R2; TMPY-02527; Q7LG56-1; Met 1-Phe 351). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 0.02% Tween 80, pH 7.0 |
| 研究背景 | Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA synthesis. Ribonucleotide reductase (RNR) is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides and plays a critical role in regulating the total rate of DNA synthesis so that DNA to cell mass is maintained at a constant ratio during cell division and DNA repair. RRM2B is a phosphorylated protein. It is hypothesized that RRM2B activity can be regulated at the posttranslational level in response to DNA damage. RRM2B has previously been shown to be essential for the maintenance of mtDNA copy number and its candidacy for tumor suppression has been evaluated in several mutational analyses of different cancer types. However, the contribution of RRM2B to the DNA damage response has been questioned because its transcriptional induction upon DNA damage is not rapid enough for prompt DNA repair. Instead, ATM-mediated phosphorylation has been suggested to regulate the DNA repair activity of RRM2B posttranslationally. Besides, a defect in RRM2B can induce a mild muscle disease of adult onset through disturbance of mitochondrial homeostasis but that this defect does not appear to be oncogenic. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human RRM2B / P53R2 protein (TMPY-02527) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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