Anti-p53 Antibody (1J151)

Name: Anti-p53 Antibody (1J151)
Brand: TargetMol
SKU: TMAY-03854
Rating: 4.5 (1 reviews)

还可以

产品编号 TMAY-03854

Anti-p53 Antibody (1J151) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (1J151) 可用于 ELISA(Cap)。

Anti-p53 Antibody (1J151)

还可以

产品编号 TMAY-03854

Anti-p53 Antibody (1J151) 是一种 Mouse 抗体，靶向 p53。Anti-p53 Antibody (1J151) 可用于 ELISA(Cap)。

产品信息正在更新中，如果您想购买，请点击大包装&定制按钮.

大包装 & 定制

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述	Anti-p53 Antibody (1J151) is a Mouse antibody targeting p53. Anti-p53 Antibody (1J151) can be used in ELISA(Cap).
Ig Type	Monoclonal Mouse IgG1
克隆号	1J151
交叉反应	Cynomolgus
应用	ELISA(Cap)
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Cynomolgus p53 ( TMPY-02228; E3U906; Met1-Asp393). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damage, hypoxia, spindle damage). Activation of p53 begins through a number of mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs. MDM2 is a ubiquitin ligase that binds p53 and targets p53 for proteasomal degradation. Phosphorylation, p14ARF and USP7 prevent MDM2-p53 interactions, leading to an increase in stable p53 tetramers in the cytoplasm. Further modifications such as methylation and acetylation lead to an increase in Tp53 binding to gene specific response elements. Tp53 regulates a large number of genes (>100 genes) that control a number of key tumor suppressing functions such as cell cycle arrest, DNA repair, senescence and apoptosis. Whilst the activation of p53 often leads to apoptosis, p53 inactivation facilitates tumor progression. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer, Li-Fraumeni syndrome, lung cancer and adrenocortical carcinoma.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Cynomolgus p53 Protein (TMPY-02228)
抗原种属	Cynomolgus
研究领域	Apoptosis Transcription Factors and Regulators, Cancer Drug Targets, Tumor Suppressors

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.