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Anti-Neuropilin-1 Antibody (3Z32)
还可以产品编号 TMAY-00058
Anti-Neuropilin-1 Antibody (3Z32) 是一种 Mouse 抗体，靶向 Neuropilin-1。Anti-Neuropilin-1 Antibody (3Z32) 可用于 FCM。
Anti-Neuropilin-1 Antibody (3Z32)
Anti-Neuropilin-1 Antibody (3Z32)
还可以产品编号 TMAY-00058
Anti-Neuropilin-1 Antibody (3Z32) 是一种 Mouse 抗体，靶向 Neuropilin-1。Anti-Neuropilin-1 Antibody (3Z32) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Neuropilin-1 Antibody (3Z32) is a Mouse antibody targeting Neuropilin-1. Anti-Neuropilin-1 Antibody (3Z32) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3Z32 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of human NRP1(CD304) expression on HUVEC cells. Cells were stained with purified anti-Human NRP1, then a PE-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Neuropilin-1 / NRP1 / CD304 (rh Neuropilin-1 / NRP1 / CD304; TMPY-02367; NP_001019799.1; Met1-Lys644). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is divided into four domains, CUB (a1/a2) domain, FV/FVIII (b1/b2) domain, MAM (c) domain, and (d) domain that contains a transmembrane and a short cytoplasmic region. Neuropilin-1 (NRP1) acts as a receptor for two different extracellular ligands, class 3 semaphorins, and specific isoforms of vascular endothelial growth factor. The functions of NRP1 and NRP2 have been extensively studied in neurons where they act in axon guidance and in endothelial cells where they promote angiogenesis and cell migration. Neuropilin-1 is likely to mediate contacts between the dendritic cells and the T lymphocytes via homotypic interactions and is essential for the initiation of the primary immune response. NRP1 is a co-receptor for VEGF receptor-2 (VEGFR2) that enhances the binding of VEGF165 to VEGFR2 and VEGF165-mediated chemotaxis. NRP1 expression is regulated in EC by tumor necrosis factor-alpha, the transcription factors dHAND and Ets-1, and vascular injury. NRP1 upregulation is positively correlated with the progression of various tumors. Overexpression of NRPI in rat tumor cells results in enlarged tumors and substantially enhanced tumor angiogenesis. On the other hand, soluble NRP1 (sNRP1) is an antagonist of tumor angiogenesis. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PE |
| 可提供抗体种类 | 3 |
| 免疫原 | Recombinant Human Neuropilin-1 / NRP1 / CD304 protein (TMPY-02367) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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