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Anti-MOB4A/MOB1B Antibody (6O289)
还可以产品编号 TMAY-02681
别名 MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2
Anti-MOB4A/MOB1B Antibody (6O289) 是一种 Mouse 抗体，靶向 MOB4A/MOB1B。Anti-MOB4A/MOB1B Antibody (6O289) 可用于 ICC/IF。
Anti-MOB4A/MOB1B Antibody (6O289)
Anti-MOB4A/MOB1B Antibody (6O289)
还可以产品编号 TMAY-02681 别名 MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2
Anti-MOB4A/MOB1B Antibody (6O289) 是一种 Mouse 抗体，靶向 MOB4A/MOB1B。Anti-MOB4A/MOB1B Antibody (6O289) 可用于 ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-MOB4A/MOB1B Antibody (6O289) is a Mouse antibody targeting MOB4A/MOB1B. Anti-MOB4A/MOB1B Antibody (6O289) can be used in ICC/IF. |
| 别名 | MOBKL1A, MOB4A, MOB kinase activator 1B, MATS2 |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 6O289 |
| 交叉反应 | Human |
| 验证活性 | Immunofluorescence staining of Human MOBKL1A in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with mouse anti-Human MOBKL1A monoclonal antibody (1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-mouse IgG secondary antibody(green) and counterstained with DAPI(blue). Positive staining was localized to cytoplasm. |
| 应用 | ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was obtained from a mouse immunized with purified, recombinant Human MOB1B / MOBKL1A (rh MOB1B / MOBKL1A; TMPY-03442; Q7L9L4; Met1-Arg216). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | MST1 and MST2 are the mammalian Ste2-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. Overexpression of MST1 or MST2 in mammalian cells is proapoptotic. MST1 and MST2 activity increase during mitosis, especially in nocodazole-arrested mitotic cells, where these kinases exhibit an increase in both abundance and activation. MST1 and MST2 also can be activated nonphysiologically by okadaic acid or H2O2. The MOB1B and MOBKL1B polypeptides, homologs of the Drosophila MATS polypeptide, are identified as preferred MST1/MST2 substrates in vitro and are phosphorylated in cells in an MST1/MST2-dependent manner in mitosis and response to okadaic acid or H2O2. MST1/MST2-catalyzed MOB1B/MOBKL1B phosphorylation alters the ability of MOB1B/MOBKL1B to bind and regulate downstream targets such as the NDR-family protein kinases. Thus, MOB1B/MOBKL1B phosphorylation in cells promotes MOB1B/MOBKL1B binding to the LATS1 kinase and enables H2O2-stimulated LATS1 activation loop phosphorylation. Most importantly, the replacement of endogenous MOB1B/MOBKL1B by a non-phosphorylatable mutant is sufficient to accelerate cell proliferation substantially by speeding progression through G1/S as well as mitotic exit. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human MOB1B / MOBKL1A Protein (TMPY-03442) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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