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Anti-Meprin alpha/MEP1A Antibody (2Q198)
还可以产品编号 TMAY-03064
Anti-Meprin alpha/MEP1A Antibody (2Q198) 是一种 Rabbit 抗体，靶向 Meprin alpha/MEP1A。Anti-Meprin alpha/MEP1A Antibody (2Q198) 可用于 ELISA,IHC-P。
Anti-Meprin alpha/MEP1A Antibody (2Q198)
Anti-Meprin alpha/MEP1A Antibody (2Q198)
还可以产品编号 TMAY-03064
Anti-Meprin alpha/MEP1A Antibody (2Q198) 是一种 Rabbit 抗体，靶向 Meprin alpha/MEP1A。Anti-Meprin alpha/MEP1A Antibody (2Q198) 可用于 ELISA,IHC-P。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-Meprin alpha/MEP1A Antibody (2Q198) is a Rabbit antibody targeting Meprin alpha/MEP1A. Anti-Meprin alpha/MEP1A Antibody (2Q198) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2Q198 |
| 交叉反应 | Mouse |
| 验证活性 | 1. Immunochemical staining of mouse MEP1A in mouse kidney with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of mouse MEP1A in mouse intestine with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse MEP1A (rM MEP1A; TMPY-01318; NP_032611.2; Met 1-Arg 615). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein that belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in the kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials, and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse MEP1A Protein (TMPY-01318) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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