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Anti-LRP1 Antibody (1R508)

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产品编号 TMAH-00704
别名 TGFBR5, LRP1A, LRP, KPA, IGFBP3R1, IGFBP-3R, IGFBP3R, DDH3, CD91, APR, APOER, A2MR

Anti-LRP1 Antibody (1R508) 是一种 Rabbit 抗体,靶向 LRP1。Anti-LRP1 Antibody (1R508) 可用于 ELISA, WB, IHC。

Anti-LRP1 Antibody (1R508)

Anti-LRP1 Antibody (1R508)

Rating icon 还可以
产品编号 TMAH-00704 别名 TGFBR5, LRP1A, LRP, KPA, IGFBP3R1, IGFBP-3R, IGFBP3R, DDH3, CD91, APR, APOER, A2MR

Anti-LRP1 Antibody (1R508) 是一种 Rabbit 抗体,靶向 LRP1。Anti-LRP1 Antibody (1R508) 可用于 ELISA, WB, IHC。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,190
5日内发货
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产品介绍

生物活性
产品描述
Anti-LRP1 Antibody (1R508) is a Rabbit antibody targeting LRP1. Anti-LRP1 Antibody (1R508) can be used in ELISA, WB, IHC.
别名TGFBR5, LRP1A, LRP, KPA, IGFBP3R1, IGFBP-3R, IGFBP3R, DDH3, CD91, APR, APOER, A2MR
Ig Type
Rabbit IgG
克隆号
1R508
交叉反应
Human, Mouse, Rat
验证活性
1. Western Blot
-Positive WB detected in: Mouse lung tissue lysate, Rat liver tissue lysate
-All lanes: LRP1 antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 505 kDa
-Observed band size: 100 kDa
2. IHC image of TMAH-00704 diluted at 1:150 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody.
3. IHC image of TMAH-00704 diluted at 1:150 and staining in paraffin-embedded mouse brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody.
应用
ELISA, WB, IHC
推荐剂量
WB:1:500-1:2000; IHC:1:50-1:200.
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位[Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm. Nucleus.; Golgi outpost. Cytoplasm, cytoskeleton, microtubule organizing center.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor. Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission. (Microbial infection) Functions as a receptor for Pseudomonas aeruginosa exotoxin A.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human LRP1
抗原种属
Human
基因ID
4035
Uniprot ID
研究领域
Neuroscience, Cancer, Cardiovascular, Cell biology, Metabolism, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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