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Anti-Kallikrein 4/KLK4 Antibody (1I345) 是一种 Rabbit 抗体,靶向 Kallikrein 4/KLK4。Anti-Kallikrein 4/KLK4 Antibody (1I345) 可用于 ELISA。
Anti-Kallikrein 4/KLK4 Antibody (1I345) 是一种 Rabbit 抗体,靶向 Kallikrein 4/KLK4。Anti-Kallikrein 4/KLK4 Antibody (1I345) 可用于 ELISA。
产品描述 | Anti-Kallikrein 4/KLK4 Antibody (1I345) is a Rabbit antibody targeting Kallikrein 4/KLK4. Anti-Kallikrein 4/KLK4 Antibody (1I345) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 1I345 |
交叉反应 | Human |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human KLK4 / Kallikrein 4 (rh KLK4 / Kallikrein 4; TMPY-01900; NP_004908.3; Met1-Ser254). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-2). The late protease is kallikrein 4 (KLK4). The principal functions of MMP-2 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of Amelogenesis Imperfecta Hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. |
偶联 | Unconjugated |
免疫原 | Recombinant Human KLK4 / Kallikrein 4 protein (TMPY-01900) |
抗原种属 | Human |
研究领域 | Serine Proteases and Regulators |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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