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Anti-Kallikrein 4/KLK4 Antibody (1I345)

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产品编号 TMAY-02117

Anti-Kallikrein 4/KLK4 Antibody (1I345) 是一种 Rabbit 抗体,靶向 Kallikrein 4/KLK4。Anti-Kallikrein 4/KLK4 Antibody (1I345) 可用于 ELISA。

Anti-Kallikrein 4/KLK4 Antibody (1I345)

Anti-Kallikrein 4/KLK4 Antibody (1I345)

Rating icon 还可以
产品编号 TMAY-02117

Anti-Kallikrein 4/KLK4 Antibody (1I345) 是一种 Rabbit 抗体,靶向 Kallikrein 4/KLK4。Anti-Kallikrein 4/KLK4 Antibody (1I345) 可用于 ELISA。

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产品介绍

生物活性
产品描述
Anti-Kallikrein 4/KLK4 Antibody (1I345) is a Rabbit antibody targeting Kallikrein 4/KLK4. Anti-Kallikrein 4/KLK4 Antibody (1I345) can be used in ELISA.
Ig Type
Monoclonal Rabbit IgG
克隆号
1I345
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human KLK4 / Kallikrein 4 (rh KLK4 / Kallikrein 4; TMPY-01900; NP_004908.3; Met1-Ser254).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Kallikrein-4, also known as Enamel matrix serine proteinase 1, Kallikrein-like protein 1, KLK-L1, Serine protease 17, KLK4, PRSS17, and EMSP1, is a secreted protein that belongs to the peptidase S1 family and Kallikrein subfamily. Kallikrein-4 / KLK4 is a serine protease expressed during enamel maturation, and proteolytic processing of the enamel matrix by KLK4 is critical for proper enamel formation. Kallikrein-4 / KLK4 contains one peptidase S1 domain. Kallikrein-4 / KLK4 is secreted by transition- and maturation-stage ameloblasts. KLK4 aggressively degrades the retained organic matrix following the termination of enamel protein secretion. Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-2). The late protease is kallikrein 4 (KLK4). The principal functions of MMP-2 and KLK4 in dental enamel formation are to facilitate the orderly replacement of organic matrix with mineral, generating an enamel layer that is harder, less porous, and unstained by retained enamel proteins. Defects in Kallikrein-4 / KLK4 are the cause of Amelogenesis Imperfecta Hypomaturation type 2A1 (AI2A1) which is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Human KLK4 / Kallikrein 4 protein (TMPY-01900)
抗原种属
Human
研究领域
Serine Proteases and Regulators
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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