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顶部生物活性储存和溶解信息计算器

Anti-IRS-1 Antibody (6O938)

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产品编号 TMAC-02240

别名 IRS-1, Insulin receptor substrate 1

Anti-IRS-1 Antibody (6O938) 是一种 Rabbit 抗体，靶向 IRS-1。Anti-IRS-1 Antibody (6O938) 可用于 ICC/IF,IHC,WB。

Anti-IRS-1 Antibody (6O938)

Anti-IRS-1 Antibody (6O938)

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产品编号 TMAC-02240 别名 IRS-1, Insulin receptor substrate 1

Anti-IRS-1 Antibody (6O938) 是一种 Rabbit 抗体，靶向 IRS-1。Anti-IRS-1 Antibody (6O938) 可用于 ICC/IF,IHC,WB。

规格价格库存数量
50 μL
¥ 1,485
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-IRS-1 Antibody (6O938) is a Rabbit antibody targeting IRS-1. Anti-IRS-1 Antibody (6O938) can be used in ICC/IF,IHC,WB.
别名IRS-1, Insulin receptor substrate 1
Ig Type
IgG
克隆号
6O938
交叉反应
Human
验证活性
1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-IRS1 antibody. Counter stained with hematoxylin.
2. ICC staining IRS1 in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining IRS1 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining IRS1 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
verifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用ICC/IFIHCWB
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The insulin receptor substrate-1 (IRS-1), a protein major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphotyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P35568
化学信息
分子量Theoretical: 170 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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