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Anti-IL-4 Antibody (9P523)
还可以产品编号 TMAY-02094
Anti-IL-4 Antibody (9P523) 是一种 Mouse 抗体，靶向 IL-4。Anti-IL-4 Antibody (9P523) 可用于 WB。
Anti-IL-4 Antibody (9P523)
Anti-IL-4 Antibody (9P523)
还可以产品编号 TMAY-02094
Anti-IL-4 Antibody (9P523) 是一种 Mouse 抗体，靶向 IL-4。Anti-IL-4 Antibody (9P523) 可用于 WB。
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| 产品描述 | Anti-IL-4 Antibody (9P523) is a Mouse antibody targeting IL-4. Anti-IL-4 Antibody (9P523) can be used in WB. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9P523 |
| 交叉反应 | Human |
| 验证活性 | Anti-IL4 mouse monoclonal antibody at 1:500 dilution. -Lane A: HL60 Whole Cell Lysate. -Lane B: Jurkat Whole Cell Lysate. -Lane C: MOLT4 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Rabbit Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:17 kDa. -Observed band size:19 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This product is a recombinant monoclonal antibody expressed from HEK293 cells. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 50mM Hepes, 100mM NaCl, 10% Trehalose, pH 8.0 |
| 研究背景 | Interleukin-4, also known as IL4, is a secreted protein that belongs to the IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low-affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Interleukin-4 is essential for the switching of B cells to IgE antibody production and the maturation of T helper (Th) cells toward the Th2 phenotype. It participates in at least several B-cell activation processes as well as other cell types. However, studies show that double mutant (Q116D, Y119D) of the murine IL4 protein (QY), both glutamine 116 and tyrosine 119, which binds to the IL4 receptor alpha, completely inhibits in a dose-dependent manner the IL4-induced proliferation of lipopolysaccharide-stimulated murine splenic B-cells, of the murine T cell line CTLL-2, and the murine pre-B-cell line BA/F3. QY also inhibited the IL4-stimulated up-regulation of CD23 expression by lipopolysaccharide-stimulated murine splenic B-cells and abolished tyrosine phosphorylation of the transcription factor Stat6 and the tyrosine kinase Jak3 in IL4-stimulated BA/F3 cells.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human IL-4 Protein (TMPY-01862) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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