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Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)
还可以产品编号 TMAH-00619
别名 interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 是一种抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 可用于 ELISA。
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)
还可以产品编号 TMAH-00619 别名 interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 是一种抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,195 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) is an antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) can be used in ELISA. |
| 别名 | interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13 |
| Ig Type | hIgG1 |
| 克隆号 | 6Q78 |
| 交叉反应 | Human, Macaca fascicularis |
| 验证活性 | 1. The Binding Activity of Macaca fascicularis IL1RAP with Anti-IL1RAP recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9099-1.181 ng/mL. 2. The Binding Activity of Human IL1RAP with Anti-IL1RAP recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9667-1.477 ng/mL. |
| 应用 | ELISA |
| 推荐剂量 | ELISA:1:5000-1:50000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human IL1RAP Protein |
| 抗原种属 | Human |
| 基因ID | 3556 |
| Uniprot ID | |
| 研究领域 | Cardiovascular, Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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