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Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)

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产品编号 TMAH-00619

别名 interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13

Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 是一种抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 可用于 ELISA。

Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)

Anti-IL-1RAP/IL-1RAcP Antibody (6Q78)

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产品编号 TMAH-00619 别名 interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13

Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 是一种抗体，靶向 IL-1RAP/IL-1RAcP。Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) 可用于 ELISA。

规格价格库存数量
50 μL
¥ 1,310
5日内发货
100 μL
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) is an antibody targeting IL-1RAP/IL-1RAcP. Anti-IL-1RAP/IL-1RAcP Antibody (6Q78) can be used in ELISA.
别名interleukin 1 receptor accessory protein, IL-1RAcP, IL1R3, C3orf13
Ig Type
hIgG1
克隆号
6Q78
交叉反应
Human, Macaca fascicularis
验证活性
1. The Binding Activity of Macaca fascicularis IL1RAP with Anti-IL1RAP recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9099-1.181 ng/mL.
2. The Binding Activity of Human IL1RAP with Anti-IL1RAP recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human IL1RAP at 2 μg/mL can bind Anti-IL1RAP recombinant antibody. The EC50 is 0.9667-1.477 ng/mL.
应用ELISA
推荐剂量
ELISA:1:5000-1:50000.
抗体种类
Monoclonal
亚细胞定位[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
组织特异性Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable). Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human IL1RAP Protein
抗原种属
Human
基因名称
IL1RAP
基因ID
3556
Uniprot ID
Q9NPH3
研究领域
Cardiovascular, Immunology
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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