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Anti-HTRA1 Antibody (3M603)
还可以产品编号 TMAH-00584
Anti-HTRA1 Antibody (3M603) 是一种抗体，靶向 HTRA1。Anti-HTRA1 Antibody (3M603) 可用于 ELISA, IHC。
Anti-HTRA1 Antibody (3M603)
Anti-HTRA1 Antibody (3M603)
还可以产品编号 TMAH-00584
Anti-HTRA1 Antibody (3M603) 是一种抗体，靶向 HTRA1。Anti-HTRA1 Antibody (3M603) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-HTRA1 Antibody (3M603) is an antibody targeting HTRA1. Anti-HTRA1 Antibody (3M603) can be used in ELISA, IHC. |
| Ig Type | hIgG1 |
| 克隆号 | 3M603 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00584 diluted at 1:200 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane. Secreted. Cytoplasm, cytosol. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human HTRA1 Protein |
| 抗原种属 | Human |
| 基因ID | 5654 |
| Uniprot ID | |
| 研究领域 | Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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