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Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847)
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产品编号 TMAY-01786
Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) 是一种 Mouse 抗体，靶向 HIV-1 (group M, subtype CRF07_BC) gp120。Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) 可用于 WB,ELISA。
Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847)
Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847)
还可以产品编号 TMAY-01786
Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) 是一种 Mouse 抗体，靶向 HIV-1 (group M, subtype CRF07_BC) gp120。Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μL | ¥ 795 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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| 产品描述 | Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) is a Mouse antibody targeting HIV-1 (group M, subtype CRF07_BC) gp120. Anti-HIV-1 (group M, subtype CRF07_BC) gp120 Antibody (1K847) can be used in WB,ELISA. |
| Ig Type | Mouse IgG2b |
| 克隆号 | 1K847 |
| 应用 | |
| 推荐剂量 | WB: his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect HIV-GP120-His in WB.; ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant HIV-1 gp120 (TMPY-01373; Ala29-Glu502; AFM77980.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: HIV-1 gp120 Protein (TMPY-01373) |
| 抗原种属 | HIV |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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