Anti-HBsAg Antibody (8A718) is a Mouse antibody targeting HBsAg. Anti-HBsAg Antibody (8A718) can be used in ELISA.

IgM

8A718

(predicted:HBsAg)

ELISA: 1:5000-10000

Monoclonal

Recombinant Protein: HBsAg protein

S

Large envelope protein

Hepatitis B

The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.