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Anti-Gremlin-1 Antibody (3L967) 是一种抗体,靶向 Gremlin-1。Anti-Gremlin-1 Antibody (3L967) 可用于 ELISA, IHC。
Anti-Gremlin-1 Antibody (3L967) 是一种抗体,靶向 Gremlin-1。Anti-Gremlin-1 Antibody (3L967) 可用于 ELISA, IHC。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 μL | ¥ 1,310 | 5日内发货 | |
100 μL | ¥ 2,180 | 5日内发货 |
产品描述 | Anti-Gremlin-1 Antibody (3L967) is an antibody targeting Gremlin-1. Anti-Gremlin-1 Antibody (3L967) can be used in ELISA, IHC. |
别名 | GREM1 |
Ig Type | hIgG1 |
克隆号 | 3L967 |
交叉反应 | Human |
验证活性 | 1. IHC image of TMAH-00512 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. 2. IHC image of TMAH-00512 diluted at 1:100 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB. |
应用 | |
推荐剂量 | IHC:1:50-1:200. |
抗体种类 | Monoclonal |
亚细胞定位 | Secreted. |
组织特异性 | Highly expressed in small intestine, fetal brain and colon. Expression is restricted to intestinal subepithelial myofibroblasts (ISEMFs) at the crypt base. In subjects with HMPS1, by contrast, GREM1 is expressed, not only in basal ISEMFs, but also at very |
构建方式 | Recombinant Antibody |
纯化方式 | Affinity-chromatography |
性状 | Liquid |
缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
研究背景 | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. |
偶联 | Unconjugated |
免疫原 | Recombinant Protein: Human GREM1 Protein |
抗原种属 | Human |
基因名称 | GREM1 |
基因ID | |
Uniprot ID | |
研究领域 | Signal transduction, Stem cells |
储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
运输方式 | Shipping with blue ice. |
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