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Anti-GHR/Growth Hormone R Antibody (4J754)

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Anti-GHR/Growth Hormone R Antibody (4J754)
产品编号 TMAY-03055
别名 growth hormone receptor

Anti-GHR/Growth Hormone R Antibody (4J754) 是一种 Rabbit 抗体，靶向 GHR/Growth Hormone R。Anti-GHR/Growth Hormone R Antibody (4J754) 可用于 IHC-P。

Anti-GHR/Growth Hormone R Antibody (4J754)
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Anti-GHR/Growth Hormone R Antibody (4J754)

Rating icon 还可以
Anti-GHR/Growth Hormone R Antibody (4J754)
产品编号 TMAY-03055 别名 growth hormone receptor

Anti-GHR/Growth Hormone R Antibody (4J754) 是一种 Rabbit 抗体，靶向 GHR/Growth Hormone R。Anti-GHR/Growth Hormone R Antibody (4J754) 可用于 IHC-P。

规格价格库存数量
20 μL
¥ 790
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-GHR/Growth Hormone R Antibody (4J754) is a Rabbit antibody targeting GHR/Growth Hormone R. Anti-GHR/Growth Hormone R Antibody (4J754) can be used in IHC-P.
别名growth hormone receptor
Ig Type
Rabbit IgG
克隆号
4J754
交叉反应
Mouse
验证活性
1. Immunochemical staining of mouse GHR in mouse stomach with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).
2. Immunochemical staining of mouse GHR in mouse kidney with rabbit monoclonal antibody (1:100, formalin-fixed paraffin embedded sections).
应用
IHC-P
推荐剂量
IHC-P: 1:50-1:200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Growth Hormone Receptor / GHR / GHBP (rM Growth Hormone Receptor / GHR / GHBP; TMPY-01448; NP_034414.2; Met1-Gln273).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Growth hormone receptor, also known as GH receptor and GHR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and type 1 subfamily. GHR contains onefibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform4of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform1 expression of GHR in placenta is predominant in chorion and decidua. Isoform4is highly expressed in placental villi. Isoform2of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform2of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse Growth Hormone Receptor / GHR / GHBP protein (TMPY-01448)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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