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Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
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产品编号 TMAY-00474
别名 Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3
Anti-GFR Alpha-3/GFRA3 Antibody (2U985) 是一种 Rabbit 抗体，靶向 GFR Alpha-3/GFRA3。Anti-GFR Alpha-3/GFRA3 Antibody (2U985) 可用于 ELISA。
Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
Anti-GFR Alpha-3/GFRA3 Antibody (2U985)
还可以产品编号 TMAY-00474 别名 Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3
Anti-GFR Alpha-3/GFRA3 Antibody (2U985) 是一种 Rabbit 抗体，靶向 GFR Alpha-3/GFRA3。Anti-GFR Alpha-3/GFRA3 Antibody (2U985) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-GFR Alpha-3/GFRA3 Antibody (2U985) is a Rabbit antibody targeting GFR Alpha-3/GFRA3. Anti-GFR Alpha-3/GFRA3 Antibody (2U985) can be used in ELISA. |
| 别名 | Y15110, GFRα3, GFRalpha3, GFR α-3/GFRA3, GDNF family receptor α3, GDNF family receptor alpha 3 |
| Ig Type | Rabbit IgG |
| 克隆号 | 2U985 |
| 交叉反应 | Human |
| 应用 | |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human GFRA3 (rh GFRA3; TMPY-01458; NP_001487.2; Met 1-Trp 382). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Glial cell line derived neurotrophic factor (GDNF) Family Receptor Alpha 3 (GFRA3) or GDNFRa3 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA3 / GDNFRa3 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The RET is a receptor tyrosine kinase representing the signal-transducing molecule of a multisubunit surface receptor complex for the GDNF, in which GFRA / GDNFRa acts as the ligand-binding component. The neurotrophic growth factor artemin binds selectively to GDNF family receptor α3 (GFRA3 / GDNFRa3), forming a molecular complex with the co-receptor RET which mediates downstream signaling. This signaling pathway has been demonstrated to play an important role in the survival and maintenance of nociceptive sensory neurons and in the development of sympathetic neurons. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human GFRA3 protein (TMPY-01458) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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