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顶部生物活性储存和溶解信息计算器

Anti-GAD67 Antibody (1N825)

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产品编号 TMAC-01594

别名 SCP, glutamate decarboxylase 1 (brain, 67kDa), GAD, CPSQ1

Anti-GAD67 Antibody (1N825) 是一种 Rabbit 抗体，靶向 GAD67。Anti-GAD67 Antibody (1N825) 可用于 IP,WB。

Anti-GAD67 Antibody (1N825)

Anti-GAD67 Antibody (1N825)

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产品编号 TMAC-01594 别名 SCP, glutamate decarboxylase 1 (brain, 67kDa), GAD, CPSQ1

Anti-GAD67 Antibody (1N825) 是一种 Rabbit 抗体，靶向 GAD67。Anti-GAD67 Antibody (1N825) 可用于 IP,WB。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-GAD67 Antibody (1N825) is a Rabbit antibody targeting GAD67. Anti-GAD67 Antibody (1N825) can be used in IP,WB.
别名SCP, glutamate decarboxylase 1 (brain, 67kDa), GAD, CPSQ1
Ig Type
IgG
克隆号
1N825
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of GAD67 on Hela cells lysates using anti-GAD67 antibody at 1/500 dilution.
verifiedActivity
应用IPWB
推荐剂量
WB: 1:500-1000; IP: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q99259
化学信息
分子量Theoretical: 67 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

glutamate decarboxylase 1CPSQ-1CPSQ 1brain, 67kDa

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