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Anti-FKBP12 Antibody (5F45)
还可以产品编号 TMAY-00539
别名 FKBP12, Fkbp1, Fkbp, FK506 binding protein 1A
Anti-FKBP12 Antibody (5F45) 是一种 Mouse 抗体，靶向 FKBP12。Anti-FKBP12 Antibody (5F45) 可用于 WB,ELISA。
Anti-FKBP12 Antibody (5F45)
Anti-FKBP12 Antibody (5F45)
还可以产品编号 TMAY-00539 别名 FKBP12, Fkbp1, Fkbp, FK506 binding protein 1A
Anti-FKBP12 Antibody (5F45) 是一种 Mouse 抗体，靶向 FKBP12。Anti-FKBP12 Antibody (5F45) 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-FKBP12 Antibody (5F45) is a Mouse antibody targeting FKBP12. Anti-FKBP12 Antibody (5F45) can be used in WB,ELISA. |
| 别名 | FKBP12, Fkbp1, Fkbp, FK506 binding protein 1A |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5F45 |
| 交叉反应 | Human |
| 验证活性 | Anti-FKBP1A mouse monoclonal antibody at 1:500 dilution. -Lane A: SH-SY5Y Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:12 kDa. -Observed band size:15 kDa |
| 应用 | WB,ELISA |
| 推荐剂量 | WB: 1:500-1:2000; ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human recombinant Human FKBP1A (rh FKBP1A; TMPY-00808; NP_463460; Met 1-Glu 108). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | FK506 binding protein 12 (FKBP12), also known as FKBP1, along with cyclophilin, are two major members of the immunophilin protein family who serve as receptors for the immunosuppressant drugs cyclosporin A and FK506. As a conserved molecule in many eukaryotes, FKBP12 has been characterized as a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans-proline residues, and is involved in several biochemical processes including protein folding, receptor signaling, protein trafficking and transcription. FKBP12 has attracted immense attention and its role in mediating the immunosuppressive functions. FKBP12 serves a dual role as a peptidyl-prolyl cis-trans isomerase and as a modulator of several cell signaling pathways. In one such role, FKBP12 interacts with and regulates the functional state of the ryanodine Ca2+ channel receptor by altering protein conformation and coordinating multi-protein complex formation. Another physiological role of FKBP12 is an interactor and a regulator of the type I serine/threonine kinase receptors of TGF-beta superfamily. Current data, derived from detailed biochemical studies as well as from functional studies in various systems, suggest that FKBP12 functions as a "guardian" for the type I receptors to prevent them from leaky signaling under sub-optimal ligand concentrations, thereby providing a molecular "gradient reader" for TGF-beta family morphogens. This aspect of FKBP12 function may be critical for cellular responsiveness to morphogenetic gradients of the TGF-beta family members during early development, serving to assure the translation of different ligand concentrations into different signaling readouts. In addition, FKBP12 may be involved in neuronal or astrocytic cytoskeletal organization and the abnormal metabolism of tau protein in Alzheimer's disease (AD) damaged neurons. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human FKBP1A protein (TMPY-00808) |
| 抗原种属 | Human |
| 研究领域 | Phosphatases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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