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顶部生物活性储存和溶解信息计算器

Anti-FGFR4 Antibody (4N679)

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Anti-FGFR4 Antibody (4N679)
产品编号 TMAY-00958
别名 TKF, JTK2, fibroblast growth factor receptor 4, CD334

Anti-FGFR4 Antibody (4N679) 是一种 Rabbit 抗体，靶向 FGFR4。Anti-FGFR4 Antibody (4N679) 可用于 ELISA。

Anti-FGFR4 Antibody (4N679)
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Anti-FGFR4 Antibody (4N679)

Rating icon 还可以
Anti-FGFR4 Antibody (4N679)
产品编号 TMAY-00958 别名 TKF, JTK2, fibroblast growth factor receptor 4, CD334

Anti-FGFR4 Antibody (4N679) 是一种 Rabbit 抗体，靶向 FGFR4。Anti-FGFR4 Antibody (4N679) 可用于 ELISA。

规格价格库存数量
100 μL
¥ 2,289
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产品介绍

生物活性
产品描述
Anti-FGFR4 Antibody (4N679) is a Rabbit antibody targeting FGFR4. Anti-FGFR4 Antibody (4N679) can be used in ELISA.
别名TKF, JTK2, fibroblast growth factor receptor 4, CD334
Ig Type
Rabbit IgG
克隆号
4N679
交叉反应
Human
应用
ELISA
推荐剂量
ELISA: 1:5000-1:10000
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human FGFR4 / CD334 (rh FGFR4 / CD334; TMPY-02112; NP_002002.3; Met1-Asp369).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human FGFR4 / CD334 protein (TMPY-02112)
抗原种属
Human
研究领域
Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs)
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

JTK-2JTK 2CD-334CD 334

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