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Anti-FGFR4 Antibody (2D158)
还可以产品编号 TMAY-00957
Anti-FGFR4 Antibody (2D158) 是一种 Mouse 抗体，靶向 FGFR4。Anti-FGFR4 Antibody (2D158) 可用于 ELISA,ELISA(Cap)。
Anti-FGFR4 Antibody (2D158)
Anti-FGFR4 Antibody (2D158)
还可以产品编号 TMAY-00957
Anti-FGFR4 Antibody (2D158) 是一种 Mouse 抗体，靶向 FGFR4。Anti-FGFR4 Antibody (2D158) 可用于 ELISA,ELISA(Cap)。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-FGFR4 Antibody (2D158) is a Mouse antibody targeting FGFR4. Anti-FGFR4 Antibody (2D158) can be used in ELISA,ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 2D158 |
| 交叉反应 | Human |
| 应用 | ELISA,ELISA(Cap) |
| 推荐剂量 | ELISA: 1:1000-1:2000; ELISA(Cap): 1:250-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human FGFR4 / CD334 (rh FGFR4 / CD334; TMPY-02112; NP_002002.3; Met 1-Asp 369). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Fibroblast growth factor receptor 4 (FGFR4) also known as CD334 antigen or tyrosine kinase related to fibroblast growth factor receptor, is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of FGFR4/CD334 interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4/CD334 preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. FGFR4/CD334 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4/CD334. Mutations in FGFR4/CD334 lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human FGFR4 / CD334 protein (TMPY-02112) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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