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顶部生物活性储存和溶解信息计算器

Anti-Endo G Antibody (1O411)

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Anti-Endo G Antibody (1O411)
产品编号 TMAC-01291
别名 NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG

Anti-Endo G Antibody (1O411) 是一种 Rabbit 抗体，靶向 Endo G。Anti-Endo G Antibody (1O411) 可用于 WB,ICC。

Anti-Endo G Antibody (1O411)

Anti-Endo G Antibody (1O411)

Rating icon 还可以
Anti-Endo G Antibody (1O411)
产品编号 TMAC-01291 别名 NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG

Anti-Endo G Antibody (1O411) 是一种 Rabbit 抗体，靶向 Endo G。Anti-Endo G Antibody (1O411) 可用于 WB,ICC。

规格价格库存数量
50 μL
¥ 1,495
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Endo G Antibody (1O411) is a Rabbit antibody targeting Endo G. Anti-Endo G Antibody (1O411) can be used in WB,ICC.
别名NUCG_HUMAN, Mitochondrial endonuclease G, FLJ27463, EndonucleaseG, Endonuclease G mitochondrial, Endonuclease G, EndoG
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of Endo G on mouse heart tissue lysate using anti-Endo G antibody at 1/500 dilution.
2. ICC staining Endo G in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining Endo G in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining Endo G in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised.
应用
WB
ICC
推荐剂量
WB: 1:500-1000; ICC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Endonuclease G (ENDOG), a nuclear encoded protein, localizes to the mitochondria. This sugar-nonspecific nuclease, responsible for major mitochondrial nuclease activity, preferentially cleaves single-stranded DNA(ssDNA). Synthesized as a propeptide with an amino-terminal presequence that targets the nuclease to mitochondria, ENDOG translocates to neuclei on apoptotic stimulation and act as a nuclease without sequence specificity. Both exonucleases and DNase I stimulate the ability of ENDOG to generate double-stranded DNA cleavage products at physiological ionic strengths, suggesting that these activities work in concert with ENDOG in apoptotic cells to ensure efficient DNA breakdown. In addition to deoxyribonuclease activities, ENDOG also has ribonuclease (RNase) and RNase H activities. ENDOG is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. ENDOG exists in the mitochondrial intermembrane space, but not in the matrix where mtDNA replication occurs. This enzyme provides an important nicking function for mitochondrial DNA specifically cleaving DNA at GC tracts. Human ENDOG maps to chromosome 9q34.11.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q14249
化学信息
分子量Theoretical: 36 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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