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Anti-DSG1 Antibody (4J92)
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产品编号 TMAC-01189
别名 Pemphigus foliaceus antigen, DGI), Desmosomal glycoprotein 1 (DG1, Desmoglein-1, CDHF4, CDHF 4, Cadherin family member 4
Anti-DSG1 Antibody (4J92) 是一种 Rabbit 抗体，靶向 DSG1。Anti-DSG1 Antibody (4J92) 可用于 WB,ICC,IF,IHC-P。
Anti-DSG1 Antibody (4J92)
Anti-DSG1 Antibody (4J92)
还可以产品编号 TMAC-01189 别名 Pemphigus foliaceus antigen, DGI), Desmosomal glycoprotein 1 (DG1, Desmoglein-1, CDHF4, CDHF 4, Cadherin family member 4
Anti-DSG1 Antibody (4J92) 是一种 Rabbit 抗体，靶向 DSG1。Anti-DSG1 Antibody (4J92) 可用于 WB,ICC,IF,IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,490 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-DSG1 Antibody (4J92) is a Rabbit antibody targeting DSG1. Anti-DSG1 Antibody (4J92) can be used in WB,ICC,IF,IHC-P. |
| 别名 | Pemphigus foliaceus antigen, DGI), Desmosomal glycoprotein 1 (DG1, Desmoglein-1, CDHF4, CDHF 4, Cadherin family member 4 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat,zebrafish |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-DSG1 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human uterus tissue using anti-DSG1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse skin tissue using anti-DSG1 antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; ICC/IF: 1:50-200; IHC-P:1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Desmogleins (dsgs) are type I membrane proteins that are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. The dsg proteins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain of dsg1, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or unusual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Cultured normal human keratinocytes express dsg1 and dsg3 mRNA, with or without dsg 2 mRNA, which indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules dsg 1 and 3 and acetylcholine receptors. |
| 偶联 | Unconjugated |
| 免疫原 | A synthesized opeptide: within N-terminal human Aldolase |
| 抗原种属 | human |
| Uniprot ID |
| 分子量 | Theoretical: 114 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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