Anti-DR6 Antibody (5R172)

Name: Anti-DR6 Antibody (5R172)
Brand: TargetMol
SKU: TMAY-00405
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00405

Anti-DR6 Antibody (5R172) 是一种 Mouse 抗体，靶向 DR6。Anti-DR6 Antibody (5R172) 可用于 ELISA。

Anti-DR6 Antibody (5R172)

还可以

产品编号 TMAY-00405

Anti-DR6 Antibody (5R172) 是一种 Mouse 抗体，靶向 DR6。Anti-DR6 Antibody (5R172) 可用于 ELISA。

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产品描述	Anti-DR6 Antibody (5R172) is a Mouse antibody targeting DR6. Anti-DR6 Antibody (5R172) can be used in ELISA.
Ig Type	Monoclonal Mouse IgG1
克隆号	5R172
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:1000-1:2000
抗体种类	Monoclonal
宿主来源	Mouse
构建方式	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TNFRSF21 / DR6 (rh TNFRSF21 / DR6; TMPY-01341; NP_055267.1; Met1-Leu350). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	TNFRSF21 (death receptor-6, DR6) is an orphan TNF receptor superfamily member and belongs to a subgroup of receptors called death receptors. This type I transmembrane receptor possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is an extensively posttranslationally modified transmembrane protein and that N- and O-glycosylations of amino acids in its extracellular part. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain, and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production, suggested that DR6 serves as an important regulatory molecule in T-helper cell activation, and is involved in inflammation and immune regulation. DR6 is expressed ubiquitously with high expression in lymphoid organs, heart, brain and pancreas. Some tumor cells overexpress DR6, typically in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion, which is subject to future investigations.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human TNFRSF21 / DR6 Protein (TMPY-01341)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.