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Anti-Dectin-1 Antibody (8R553)
还可以产品编号 TMAY-03187
Anti-Dectin-1 Antibody (8R553) 是一种 Rabbit 抗体，靶向 Dectin-1。Anti-Dectin-1 Antibody (8R553) 可用于 ICC/IF。
Anti-Dectin-1 Antibody (8R553)
Anti-Dectin-1 Antibody (8R553)
还可以产品编号 TMAY-03187
Anti-Dectin-1 Antibody (8R553) 是一种 Rabbit 抗体，靶向 Dectin-1。Anti-Dectin-1 Antibody (8R553) 可用于 ICC/IF。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Dectin-1 Antibody (8R553) is a Rabbit antibody targeting Dectin-1. Anti-Dectin-1 Antibody (8R553) can be used in ICC/IF. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8R553 |
| 交叉反应 | Mouse |
| 验证活性 | Immunofluorescence staining of mouse Dectin-1 in Raw264.7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse Dectin-1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). |
| 应用 | ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Dectin-1 / CLEC7A (rM Dectin-1 / CLEC7A; TMPY-01387; NP_064392.2; Phe69-Leu244). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Mouse Dectin-1 / CLEC7A protein (TMPY-01387) |
| 抗原种属 | Mouse |
| 研究领域 | ITIM/ITAM Immunoreceptors and Related Molecules |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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