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顶部生物活性储存和溶解信息计算器

Anti-CYP1A2 Antibody (9F602)

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产品编号 TMAH-00328

别名 EC 1.14.14.1, Cytochrome P450-P3, Cytochrome P450 4, Cytochrome P450 1A2, Cytochrome P(3)450, CYPIA2, CYP1A2, Cholesterol 25-hydroxylase

Anti-CYP1A2 Antibody (9F602) 是一种抗体，靶向 CYP1A2。Anti-CYP1A2 Antibody (9F602) 可用于 ELISA,IHC,WB。

Anti-CYP1A2 Antibody (9F602)

Anti-CYP1A2 Antibody (9F602)

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Rating icon 还可以
产品编号 TMAH-00328 别名 EC 1.14.14.1, Cytochrome P450-P3, Cytochrome P450 4, Cytochrome P450 1A2, Cytochrome P(3)450, CYPIA2, CYP1A2, Cholesterol 25-hydroxylase

Anti-CYP1A2 Antibody (9F602) 是一种抗体，靶向 CYP1A2。Anti-CYP1A2 Antibody (9F602) 可用于 ELISA,IHC,WB。

规格价格库存数量
50 μL
¥ 1,310
5日内发货
100 μL
¥ 2,190
5日内发货
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产品介绍

生物活性
产品描述
Anti-CYP1A2 Antibody (9F602) is an antibody targeting CYP1A2. Anti-CYP1A2 Antibody (9F602) can be used in ELISA,IHC,WB.
别名EC 1.14.14.1, Cytochrome P450-P3, Cytochrome P450 4, Cytochrome P450 1A2, Cytochrome P(3)450, CYPIA2, CYP1A2, Cholesterol 25-hydroxylase
Ig Type
Rabbit IgG
克隆号
9F602
交叉反应
Human
验证活性
1. Western Blot
-Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, L02 whole cell lysate
-All lanes: CYP1A2 antibody at 1:1000
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 59 kDa
-Observed band size: 59 kDa
2. IHC image of TMAH-00328 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用ELISAIHCWB
推荐剂量
WB:1:500-1:5000; IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
组织特异性Liver.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid. Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer. Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA. May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin. Metabolizes caffeine via N3-demethylation (Probable).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human Cytochrome P450 1A2
抗原种属
Human
基因名称
CYP1A2
基因ID
1544
Uniprot ID
P05177
研究领域
Cancer, Cardiovascular, Metabolism, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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