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顶部生物活性储存和溶解信息计算器

Anti-Cyclophilin A Antibody (4Y81)

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产品编号 TMAC-01052

别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA

Anti-Cyclophilin A Antibody (4Y81) 是一种 Rabbit 抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4Y81) 可用于 IHC,WB。

Anti-Cyclophilin A Antibody (4Y81)

Anti-Cyclophilin A Antibody (4Y81)

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Rating icon 还可以
产品编号 TMAC-01052 别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA

Anti-Cyclophilin A Antibody (4Y81) 是一种 Rabbit 抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4Y81) 可用于 IHC,WB。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cyclophilin A Antibody (4Y81) is a Rabbit antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4Y81) can be used in IHC,WB.
别名peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Ig Type
IgG
克隆号
4Y81
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Cyclophilin A on different cells lysates using anti-Cyclophilin A antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: A431, Lane 3: HepG2.
2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
4. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
5. Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin.
verifiedActivityverifiedActivityverifiedActivityverifiedActivityverifiedActivity
应用IHCWB
推荐剂量
WB: 1:1000-5000; IHC: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P62937
化学信息
分子量Theoretical: 18 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

peptidylprolyl isomerase Acyclophilin A

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