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Anti-Cyclophilin A Antibody (4Y81)
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产品编号 TMAC-01052
别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4Y81) 是一种 Rabbit 抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4Y81) 可用于 WB,IHC。
Anti-Cyclophilin A Antibody (4Y81)
Anti-Cyclophilin A Antibody (4Y81)
还可以产品编号 TMAC-01052 别名 peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA
Anti-Cyclophilin A Antibody (4Y81) 是一种 Rabbit 抗体，靶向 Cyclophilin A。Anti-Cyclophilin A Antibody (4Y81) 可用于 WB,IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
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抗原信息
化学信息
| 产品描述 | Anti-Cyclophilin A Antibody (4Y81) is a Rabbit antibody targeting Cyclophilin A. Anti-Cyclophilin A Antibody (4Y81) can be used in WB,IHC. |
| 别名 | peptidylprolyl isomerase A (cyclophilin A), HEL-S-69p, CYPH, CYPA |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Cyclophilin A on different cells lysates using anti-Cyclophilin A antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: A431, Lane 3: HepG2. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-Cyclophilin A antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-5000; IHC: 1:50-200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The immunosuppressant cyclosporin A (CsA) forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of the CsA and is encoded by a single unique gene conserved from yeast to humans. CyPA is known for its involvement in T cell differentiation and proliferation and is highly expressed in brain. CyPA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication. Cyclophilin B (CyPB) is a member of the cyclophilin family with specific N- and C-terminal extensions. Unlike CyPA, CyPB has a signal sequence leading to its translocation in the endoplasmic reticulum. CyPB is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes (9,10). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 18 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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